A haplome alignment and reference sequence of the highly polymorphic Ciona savignyi genome
نویسندگان
چکیده
منابع مشابه
Assembly of polymorphic genomes: algorithms and application to Ciona savignyi.
Whole-genome assembly is now used routinely to obtain high-quality draft sequence for the genomes of species with low levels of polymorphism. However, genome assembly remains extremely challenging for highly polymorphic species. The difficulty arises because two divergent haplotypes are sequenced together, making it difficult to distinguish alleles at the same locus from paralogs at different l...
متن کاملDiploid genome reconstruction of Ciona intestinalis and comparative analysis with Ciona savignyi.
One of the main goals in genome sequencing projects is to determine a haploid consensus sequence even when clone libraries are constructed from homologous chromosomes. However, it has been noticed that haplotypes can be inferred from genome assemblies by investigating phase conservation in sequenced reads. In this study, we seek to infer haplotypes, a diploid consensus sequence, from the genome...
متن کاملUsing a custom Ciona intestinalis genome browser to visualize genomic conservation with Ciona savignyi
We have successfully designed a custom genome browser for visualization of the genome of the invertebrate chordate Ciona intestinalis. We describe the use of the genome browser to visualize the conservation between Ciona intestinalis and a related species, Ciona savignyi. Visualizing genomic conservation between these two organisms is important for determining genes and regulatory regions that ...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Genome-wide synteny through highly sensitive sequence alignment: Satsuma
MOTIVATION Comparative genomics heavily relies on alignments of large and often complex DNA sequences. From an engineering perspective, the problem here is to provide maximum sensitivity (to find all there is to find), specificity (to only find real homology) and speed (to accommodate the billions of base pairs of vertebrate genomes). RESULTS Satsuma addresses all three issues through novel s...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2007
ISSN: 1465-6906
DOI: 10.1186/gb-2007-8-3-r41